Serveur d'exploration MERS

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Searching for an ideal vaccine candidate among different MERS coronavirus receptor-binding fragments—The importance of immunofocusing in subunit vaccine design

Identifieur interne : 001A90 ( Main/Exploration ); précédent : 001A89; suivant : 001A91

Searching for an ideal vaccine candidate among different MERS coronavirus receptor-binding fragments—The importance of immunofocusing in subunit vaccine design

Auteurs : Cuiqing Ma [États-Unis] ; Lili Wang [États-Unis] ; Xinrong Tao [États-Unis] ; Naru Zhang [États-Unis] ; Yang Yang [États-Unis] ; Chien-Te K. Tseng [États-Unis] ; Fang Li [États-Unis] ; Yusen Zhou [République populaire de Chine] ; Shibo Jiang [États-Unis, République populaire de Chine] ; Lanying Du [États-Unis]

Source :

RBID : PMC:4194190

Descripteurs français

English descriptors

Abstract

Highlights

We express five MERS-CoV RBDs spanning S350-588, 358-588, 367-588, 377-606, and 377-588.

S377-588, 367-588 and 358-588 have the highest receptor binding ability than others.

S377-588 and 367-588 induced the highest-titer of IgG antibodies in mice.

S377-588 elicits highest neutralization in mice and high neutralization in rabbits.

S377-588 contains stably folded RBD structure and major neutralizing epitopes.


Url:
DOI: 10.1016/j.vaccine.2014.08.086
PubMed: 25240756
PubMed Central: 4194190


Affiliations:


Links toward previous steps (curation, corpus...)


Le document en format XML

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<wicri:regionArea>Key Laboratory of Medical Molecular Virology of Ministries of Education and Health, Shanghai Medical College and Institute of Medical Microbiology, Fudan University, Shanghai</wicri:regionArea>
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<p>
<list list-type="simple" id="lis0005">
<list-item id="lsti0005">
<label></label>
<p id="par0005">We express five MERS-CoV RBDs spanning S350-588, 358-588, 367-588, 377-606, and 377-588.</p>
</list-item>
<list-item id="lsti0010">
<label></label>
<p id="par0010">S377-588, 367-588 and 358-588 have the highest receptor binding ability than others.</p>
</list-item>
<list-item id="lsti0015">
<label></label>
<p id="par0015">S377-588 and 367-588 induced the highest-titer of IgG antibodies in mice.</p>
</list-item>
<list-item id="lsti0020">
<label></label>
<p id="par0020">S377-588 elicits highest neutralization in mice and high neutralization in rabbits.</p>
</list-item>
<list-item id="lsti0025">
<label></label>
<p id="par0025">S377-588 contains stably folded RBD structure and major neutralizing epitopes.</p>
</list-item>
</list>
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</TEI>
<affiliations>
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<country>
<li>République populaire de Chine</li>
<li>États-Unis</li>
</country>
<region>
<li>Minnesota</li>
<li>Texas</li>
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<region name="État de New York">
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<country name="République populaire de Chine">
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<name sortKey="Jiang, Shibo" sort="Jiang, Shibo" uniqKey="Jiang S" first="Shibo" last="Jiang">Shibo Jiang</name>
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</tree>
</affiliations>
</record>

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